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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K5
All Species:
14.55
Human Site:
T171
Identified Species:
22.86
UniProt:
Q13163
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13163
NP_002748.1
448
50112
T171
Q
D
I
R
Y
R
D
T
L
G
H
G
N
G
G
Chimpanzee
Pan troglodytes
XP_001174798
467
51808
T171
Q
D
I
R
Y
R
D
T
L
G
H
G
N
G
G
Rhesus Macaque
Macaca mulatta
XP_001111645
449
50213
L172
D
I
R
Y
R
D
T
L
G
H
G
N
G
G
T
Dog
Lupus familis
XP_852868
288
32448
V36
G
K
I
L
A
V
K
V
I
L
L
D
I
T
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVS7
448
50086
T171
Q
D
I
R
Y
R
D
T
L
G
H
G
N
G
G
Rat
Rattus norvegicus
Q62862
448
50179
T171
Q
D
I
R
Y
R
D
T
L
G
H
G
N
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516129
399
44778
P122
Q
D
I
E
N
R
E
P
L
G
H
G
N
G
G
Chicken
Gallus gallus
NP_001073184
351
39168
N99
R
D
I
L
G
H
G
N
G
G
T
V
Y
K
A
Frog
Xenopus laevis
NP_001084729
448
49926
I171
L
D
I
Q
C
R
D
I
L
G
H
G
N
G
G
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
K109
S
G
V
I
M
A
V
K
R
I
R
A
T
V
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24324
396
43851
E139
R
E
L
K
V
L
H
E
C
N
F
P
H
I
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10664
387
42776
S128
A
V
L
H
K
C
N
S
P
F
I
V
G
F
Y
Sea Urchin
Strong. purpuratus
XP_786275
385
43129
A121
A
G
A
V
P
K
G
A
D
S
G
I
S
L
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94A06
354
39192
N102
A
L
K
V
I
Q
L
N
T
E
E
S
T
C
R
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
E365
D
E
L
E
F
L
D
E
L
G
H
G
N
Y
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.3
99.5
63.3
N.A.
97.7
98.2
N.A.
82.3
74.1
84.8
30.5
N.A.
35
N.A.
37
49.3
Protein Similarity:
100
93.3
99.5
64.2
N.A.
99.1
99.1
N.A.
86.1
76.1
89.9
47.3
N.A.
54.2
N.A.
53.7
63.1
P-Site Identity:
100
100
6.6
6.6
N.A.
100
100
N.A.
73.3
20
73.3
0
N.A.
0
N.A.
0
6.6
P-Site Similarity:
100
100
6.6
13.3
N.A.
100
100
N.A.
80
26.6
80
6.6
N.A.
33.3
N.A.
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
30.8
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
47.5
42.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
0
7
0
7
7
0
7
0
0
0
7
0
0
7
% A
% Cys:
0
0
0
0
7
7
0
0
7
0
0
0
0
7
0
% C
% Asp:
14
47
0
0
0
7
40
0
7
0
0
7
0
0
0
% D
% Glu:
0
14
0
14
0
0
7
14
0
7
7
0
0
0
0
% E
% Phe:
0
0
0
0
7
0
0
0
0
7
7
0
0
7
0
% F
% Gly:
7
14
0
0
7
0
14
0
14
54
14
47
14
47
54
% G
% His:
0
0
0
7
0
7
7
0
0
7
47
0
7
0
0
% H
% Ile:
0
7
54
7
7
0
0
7
7
7
7
7
7
7
0
% I
% Lys:
0
7
7
7
7
7
7
7
0
0
0
0
0
7
0
% K
% Leu:
7
7
20
14
0
14
7
7
47
7
7
0
0
7
7
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
7
14
0
7
0
7
47
0
7
% N
% Pro:
0
0
0
0
7
0
0
7
7
0
0
7
0
0
0
% P
% Gln:
34
0
0
7
0
7
0
0
0
0
0
0
0
0
0
% Q
% Arg:
14
0
7
27
7
40
0
0
7
0
7
0
0
0
7
% R
% Ser:
7
0
0
0
0
0
0
7
0
7
0
7
7
0
0
% S
% Thr:
0
0
0
0
0
0
7
27
7
0
7
0
14
7
7
% T
% Val:
0
7
7
14
7
7
7
7
0
0
0
14
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
27
0
0
0
0
0
0
0
7
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _